High importance
Sep 25, 2026
To report a case of spontaneous rupture of the urinary bladder (SRUB) in a patient with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome).
The case involves a 60-year-old woman with known Osler-Weber-Rendu disease who underwent minimally invasive surgical management after excluding common causes of SRUB. The surgical intervention was focused on addressing the rupture and associated complications.
Successful management of SRUB was achieved through minimally invasive surgery, marking a notable case of such an event occurring in a patient with Osler-Weber-Rendu syndrome.
This is a single case report, limiting generalizability; further studies are needed to understand the prevalence and mechanisms of SRUB in patients with HHT.
This case highlights a potential complication of hereditary hemorrhagic telangiectasia that has not been widely documented, raising awareness about the risks of urinary bladder involvement in patients with this syndrome.
Spontaneous rupture of urinary bladder (SRUB) is a rare condition with no standard of care and significant related morbidity and mortality. Several predisposing factors have been reported, including malignancy, cystitis, binge drinking, bladder outlet obstruction, and connective tissue disorders. We describe the successful minimally invasive surgical management of a SRUB in a 60-years-old woman with known Osler-Weber-Rendu disease. After exclusion of all other recognized causes of spontaneous rupture of urinary bladder, perforation was considered most likely related to chronic inflammatory involvement of the urinary bladder, possibly associated to hereditary haemorrhagic telangiectasia. Although urinary bladder involvement in Osler-Weber-Rendu disease has been documented, typically presenting as hematuria secondary to telangiectatic lesions, to our knowledge this is the first reported case of a spontaneous rupture of urinary bladder associated with hereditary hemorrhagic telangiectasia.